Silica, silicosis, and lung cancer.
نویسندگان
چکیده
Evidence that crystalline silica is associated with an increased rate of lung cancer led the International Agency for Research on Cancer to conclude in 1997 that crystalline silica is a known human carcinogen. In Israel too, crystalline silica is considered as such. The decision raised a debate in the scientific arena, and a few scientists have questioned the basis upon which causality was determined. We review the literature regarding the level of evidence of crystalline silica carcinogenicity.
منابع مشابه
Risk assessment of mortality from silicosis and lung cancer Workers in machine factories and traditional brick production workshops with crystalline silica
Introduction: Exposure to dust is an essential factor in the brick production industry. Determining the mortality rate from silicosis and lung cancer is very important in exposure to crystalline silica dust. Therefore, this study was conducted to risk assessment of workers in machine factories and traditional brick production workshops. Materials and Methods: This cross-sectional study was con...
متن کاملتعیین میزان مواجهه ی شغلی کارگران واحد ماهیچه گیری با گرد و غبار سیلیس کریستالی تنفسی
Introduction: Occupational exposure to crystalline silica increases the risk of lung cancer and restrictive lung disease with extensive fibrosis. Silica dust is a major health hazard in foundry factories. The aim of this study was to determine core making workers’ exposure to respirable crystalline silica dust in a foundry factory. Material and Method: This cross-sectional study was conducte...
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It remains controversial whether silica is a human lung carcinogen. In this study, we estimated the relative risks of lung cancer due to silica and silicosis by meta-analysis. We collected papers published from 1966-2001 which epidemiologically reported on the relationship between silica/silicosis and lung cancer. We removed papers which did not exclude the effects of asbestos and radioactive m...
متن کاملCrystalline silica exposure, radiological silicosis, and lung cancer mortality in diatomaceous earth industry workers.
BACKGROUND The role of silicosis as either a necessary or incidental condition in silica associated lung cancer remains unresolved. To address this issue a cohort analysis of dose-response relations for crystalline silica and lung cancer mortality was conducted among diatomaceous earth workers classified according to the presence or absence of radiological silicosis. METHODS Radiological sili...
متن کاملSilica, compensated silicosis, and lung cancer in Western Australian goldminers.
OBJECTIVES Silica has recently been reclassified as carcinogenic to humans based largely on the observed increase in rates of lung cancer in subjects with silicosis. Other recent reviews have arrived at different conclusions as to whether silicosis or silica itself is carcinogenic. This study aims to examine exposure-response relations between exposure to silica and subsequent silicosis and lun...
متن کاملSilica exposure, smoking, silicosis and lung cancer--complex interactions.
BACKGROUND Establishing a clear relationship between workplace exposures and cancer is often difficult. The latent period for cancer development can make it difficult to establish a definite cause-effect relationship. The picture is further complicated by variable job histories, concomitant exposure to other carcinogens and other factors such as genetic susceptibility and poor nutrition. The la...
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ورودعنوان ژورنال:
- The Israel Medical Association journal : IMAJ
دوره 8 2 شماره
صفحات -
تاریخ انتشار 2006